Heterologous regeneration is achieved through injection or application of synthetic substances, obtained in the laboratory or, for example, from plants.

Hyaluronic acid: There are certain types of hyaluronic acid, defined as low molecular weight, which potentially can bring benefits. Unfortunately, this has not yet been scientifically proven except in a few cases.

Polynucleotides: The same applies to polynucleotides as with hyaluronic acid.

Plant exosomes: Currently very popular, they have interesting potential as topicals, in the form of ointment preparations, but their introduction into tissues with a needle is prohibited.